– Geoffrey Sher, MD
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Embryos & Genetic Testing
PGS tested Ivf failed — Amna S.
Dr. Geoffrey Sher answered
Embryo karyotype (as assessed by PGS/PGT) is a very important determinant of "competency" (the ability to propagate a viable pregnancy) but it is by no means the only factor! Whenever a patient fails to achieve a viable pregnancy following embryo transfer (ET), the first question asked is why!…
Embryos & Genetic Testing
I have an embryo that has a monosomy but I would like to transfer it. I have had two clinics refuse to transfer. Specifically I have a 45 XX (-14) I figured it’s incompatible with life if results are accurate… — Charity H.
Dr. Geoffrey Sher answered
Human embryo development occurs through a process that encompasses reprogramming, sequential cleavage divisions and mitotic chromosome segregation and embryonic genome activation. Chromosomal abnormalities may arise during germ cell and/or preimplantation embryo development and represents a major cause of early pregnancy loss. About a decade ago, I and my…
Embryos & Genetic Testing
Hello Dr. Sher, I am a 49 year old female with two miscarriages behind me. In both cases the embryos were found to be genetically abnormal. My husband and I have two genetically normally (tested) embryos from our younger days… — Mary W.
Dr. Geoffrey Sher answered
At 49-50y, you really do not want a multiple pregnancy...So I would advise transferring one at a timer. Good luck! Geoff Sher ADDITIONAL INFORMATION: I am attaching online links to two E-books which I recently co-authored with my partner at SFS-NY (Drew Tortoriello MD)....... for your reading pleasure:…
Egg Health & Ovarian Reserve
Hello, I am 41 years old. I am a friend of Ivan Sher's for many years and he mentioned I could get some help from Dr. Sher on here. My AMH levels are 2.87. We started IVF when I was… — Mash P.
Dr. Geoffrey Sher answered
I am flattered that Ivan referred you to me and will do my best to advise. The response will be lengthy but please read it carefully: There are several issues that apply here 1, AGE: It is primarily the egg (rather than the sperm) that determines the chromosomal…
Embryos & Genetic Testing
Hi Dr Sher, I listened to you on The Egg Whisperer podcast. I found your way of explaining and just the overall wealth of knowledge you proved in just a couple of podcasts so incredibly helpful. Thank you for everting… — Danielle B.
Dr. Geoffrey Sher answered
Thank you for your communication. First , let me say that IUI in a woman over 40Y bis usually not a good idea. The baby rate is about 2-3% per cycle . And with diminished ovarian reserve (DOR), you do not have the time to waste on an…
Early Pregnancy & hCG
Hi Dr Sher, I recently found out I'm pregnant with a chromosomally normal embryo and have had two Beta HCG tests, which have shown my levels are increasing as expected: First Beta HCG: 12 days past 6 day transfer =… — Mary T.
Dr. Geoffrey Sher answered
Very likely this will be a viable pregnancy (probably---80%+). Good luck! Geoffrey Sher Each and every patient/couple, in undergoing IVF makes huge emotional, physical and (in most cases) also financial investment. The fact that receiving the result of the blood human chorionic gonadotropin (hCG) pregnancy test represents the…
Embryos & Genetic Testing
Dr. Sher, We got the following PGT tested embryos from our first round of IVF at 33: two 4aa, one 3aa, one 3ab, two 5bb (six total genetic normals out of 10 that made it to blast). One of the… — Mary P.
Dr. Geoffrey Sher answered
I would not test the "inconclusive" blastocyst. In my opinion, 2ndary testing is too traumatic on trhe embryo. I would also not do another ER. You had a good result and all things being equal (e.g., the absence of an implantation dysfunction) you should be able to ave…
Embryos & Genetic Testing
Need your support to access my ebryos by AI — Prashant S.
Dr. Geoffrey Sher answered
Not sure how to advise you! Sorry! Geoff Sher ADDITIONAL INFORMATION: I am attaching online links to two E-books which I recently co-authored with my partner at SFS-NY (Drew Tortoriello MD)....... for your reading pleasure: 1.From In Vitro Fertilization to Family: A Journey with Sher Fertility Solutions (SFS)…
Early Pregnancy & hCG
Hello Dr. Sher, We transferred a single 5-day blastocyst January 30th. Our first hcg level was 1005 miu/ml at 14 days post-transfer, and 2nd hcg was 2200 miu/ml at 16 days. Two fetuses were present when we went in for… — Ian M.
Dr. Geoffrey Sher answered
In my opinion, the chance that the 2nd twin will be OK, is good! G-d bless and good luck! Geoff Sher
Embryos & Genetic Testing
After having had several failed implantations of healthy embryos, I did blood tests and obtained very high values of Factor X activity, clothing, and Factor XII activity clothing. What does it mean and how does it affect me? What's the… — Sofia G.
Dr. Geoffrey Sher answered
I really don't think this is likely to be a problem. Geoff Sher ADDITIONAL INFORMATION: I am attaching online links to two E-books which I recently co-authored with my partner at SFS-NY (Drew Tortoriello MD)....... for your reading pleasure: 1.From In Vitro Fertilization to Family: A Journey with…
Embryos & Genetic Testing
Hello Dr Sher! I was wondering if any of these "aneuploid" embryos stand a chance? I was wondering if I could maybe implant any, and if yes can I implant more than one at a time? Thank you :) 1.… — Tina F.
Dr. Geoffrey Sher answered
If any are"mosaic" they could auto correct in the uterus. Discuss with your RE. EMBRYO MOSAICISM: WHAT IS IT AND WHAT ARE THE CONSEQUENCES? Geoffrey Sher MD Human embryo development occurs through a process that encompasses reprogramming, sequential cleavage divisions and mitotic chromosome segregation and embryonic genome activation.…
Embryos & Genetic Testing
After four losses (ages 23, 32, and 33) I was diagnosed with one copy of PAI-1 and one copy of MTHFR. I also have very high thyroid antibodies. Could all of this be causing the losses? We are moving on… — Mary P.
Dr. Geoffrey Sher answered
I doubt that the heterozygous PAI-1 and one copy of MTHFR can explain the losses. the thyroid antibodies is however another matter ...see below. Geoff Sher Between 2% and 5% of women of the childbearing age have reduced thyroid hormone activity (hypothyroidism). Women with hypothyroidism often manifest with…
Embryos & Genetic Testing
Hi! We just had our baby girl (4BB). Are the odds better doing a transfer for a second child since the first one worked? We had MFI and are 28! We transferred two embryos the first time (4AA & 4BB)… — Megan W.
Dr. Geoffrey Sher answered
I think your chance of success is good. I personally am willing to transfer up to 2 embryos at a time unless there is a specific obstetrics contraindication against twins. Geoff Sher ADDITIONAL INFORMATION: I am attaching online links to two E-books which I recently co-authored with my…
Embryos & Genetic Testing
We are planning to transfer our previous frozen embryo, and I did currently semen analysis and found uroplasma, do my wife need an antibiotic before transferring the frozen embryo, and if yes what is the antibiotic and what is the… — Yousef S.
Dr. Geoffrey Sher answered
Ureaplasma urealyticum is a bacterium that belongs to the mycoplasma family. It can be detected in the reproductive tract of as many as 40% of individuals (male and female). Ureaplasma probably does not prevent normal conception in the majority of cases, because by and large, the uterine cavity…
Embryos & Genetic Testing
Hello, my husband and I have had a total of 6 good/top quality day 5 embryos implanted over the course of 2 years (2021- present). I have endometriosis, which I had surgery for in 2021. Following this surgery we had… — Ashley C.
Dr. Geoffrey Sher answered
Implantation dysfunction is unfortunately often overlooked as an important cause of IVF failure. This is especially relevant in cases of unexplained IVF failure, recurrent pregnancy loss (RPL), and in women with underlying endo-uterine surface lesions, thickness of the uterine lining (endometrium) and /or immunologic factors. IVF success rates…
