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Our Medical Directors are outstanding physicians that you will find to be very personable and compassionate, who take care to ensure that you have the most cutting-edge fertility treatments at your disposal. This is your outlet to ask your questions to the doctors.

Dear Patients,

I created this forum to welcome any questions you have on the topic of infertility, IVF, conception, testing, evaluation, or any related topics. I do my best to answer all questions in less than 24 hours. I know your question is important and, in many cases, I will answer within just a few hours. Thank you for taking the time to trust me with your concern.

– Geoffrey Sher, MD

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Immunology & Implantation Sep 21, 2026

IVIG and Reproductive Immunology

Hello Dr. Sher, My wife and I have experienced 3 miscarriages of euploid embryos. Our Dr. did a variety of tests that came back normal, so we are moving forward with immunological testing. We ordered the Pregmune test and are… — Matthew J.

Dr. Geoffrey Sher answered

If you do indeed have activated NK cells (NKa) , you wont need IVIG. It has been supplanted by Intralipid which is much less expensive. We should talk online. Call my assistant, Patti at 702-281-7437 and set up an online consultation with me. Geoff Sher Understanding Recurrent Pregnancy…
Egg Health & Ovarian Reserve Jul 6, 2026

Hashimotos DOR- Protocol

Hello Dr, I’m 37 years old and have Hashimotos and Diminished ovarian reserve what t protocol would you recommend for me — Emoata O.

Dr. Geoffrey Sher answered

Here is some informaion on the effect of Hashimoto's on embryo implantation. Unfortunately I would need a lot more information to recommend a protocol for you. I suggest you contact Patti at concierge@sherIVF.com and set up an online consultation to talk it through with me. Geoff Sher Thyroid…
Immunology & Implantation Jun 1, 2026

Intralipid/IVIG

Do you administer Intralipid/IVIG even if I’m a patient of another fertility clinic? — María P.

Dr. Geoffrey Sher answered

Absolutely, we do Unlocking the potential of intralipid therapy in IVF: a revolutionary approach to enhancing Implantation Intralipid (IL) is not just any solution; it’s a medical marvel. Picture this: tiny droplets of lipid, similar to what you’d find in soybean oil and egg yolks, floating in water.…
Immunology & Implantation Feb 13, 2026

Hashimoto-NK toxicity

Dear Dr. Sher, I have a diagnosed Hashimoto‘s disease with high thyroid antibodies >1500. We tried naturally for a while but nothing happend. I am 33 and my husband is 34 yeras old. I recently tested my NK cell acitivation… — Anna G.

Dr. Geoffrey Sher answered

Between 2% and 5% of women of the childbearing age have reduced thyroid hormone activity (hypothyroidism). Women with hypothyroidism often manifest with reproductive failure i.e. infertility, unexplained (often repeated) IVF failure, or recurrent pregnancy loss. The condition is 5-10 times more common in women than in men. In…
Immunology & Implantation Nov 6, 2025

Reproductive Immunology

Hello, I have had two, late, second trimester losses, back to back. Both of these losses have happened since I was diagnosed with a rare autoimmune, eosinophillic esophagitis. What is your familiarity with reproductive immunology and how likely is there… — Kathryn C.

Dr. Geoffrey Sher answered

In the world of assisted reproduction, when IVF fails repeatedly or without explanation, it's often assumed that poor embryo quality is the main culprit. However, this view oversimplifies the situation. The process of embryo implantation, which begins about six or seven days after fertilization, involves a complex interaction…
Immunology & Implantation Aug 19, 2025

covid

Hi, Dr Sher I got COVID 1 day prior to FET My FET was cancelled They say I can proceed next cycle. Do you agree that next cycle we can proceed or should be a longer washout period to allow… — Carmela R.

Dr. Geoffrey Sher answered

I agree with the advice given by your doctor! Good luck! Geoff Sher
Immunology & Implantation Aug 15, 2025

implantation dysfunction

Listened to you on a podcast recently and appreciate you so much for sharing your knowledge on this topic. Wondering if you have any input for next steps after 2 implantation failures (of 5AA embryos without PGT-A testing, female age… — Ashley S.

Dr. Geoffrey Sher answered

Implantation dysfunction is often overlooked as a significant reason for IVF failure. This is especially true when IVF failure is unexplained, or when there are recurring pregnancy losses or underlying issues with the uterus, such as endo-uterine surface lesions, thin uterine lining (endometrium), or immunological factors. IVF success…
Immunology & Implantation May 29, 2025

Dexamethasone for FET

What would be the reason for using Dexamethasone (short 5 day course) leading up to FET vs using Prednisone? I feel like prednisone is more commonly prescribed for this purpose, but my doctor said there is no difference. I recently… — Renee G.

Dr. Geoffrey Sher answered

The two are by and large interchangeable. The steroid administration should start at the beginning of the cycle and continue to the 10th week. It should then be tailed off over 2 weeks. Geoff Sher _ In the world of assisted reproduction, when IVF fails repeatedly or without…
Early Pregnancy & hCG May 8, 2025

LIT in pregnancy

Hi Dr, My partner and I are a partial DQ Alpha match so had 2x LIT treatment, one before transfer and one at 6 weeks and ongoing intralipids bi-weekly. I am currently 15 weeks pregnant with scans looking good. I… — Victoria L.

Dr. Geoffrey Sher answered

UNDERSTANDING RECURRENT PREGNANCY LOSS ( RPL): CAUSES AND SOLUTIONS. When it comes to reproduction, humans face challenges compared to other mammals. A significant number of fertilized eggs in humans do not result in live births, with up to 75% failing to develop, and around 30% of pregnancies ending…
Immunology & Implantation May 8, 2025

Implantation Failure – BCL6, immature nk cells & APS

Hello Dr, After multiple implantation failure, I was diagnosed with anti-phospholipid syndrom (managed with daily asprin and in case of pregnancy clexane) but also high inflammation marker BCL6 (though no endometriosis) and immature NK cells / low local immune activation… — Kate F.

Dr. Geoffrey Sher answered

I have strong suspicion that you have an immunologic implantation dysfunction. IVF FAILURE WITH “NORMAL” EMBRYOS: EXAMINING AND ADDRESSING ANATOMICAL AND IMMUNOLOGIC CAUSES. Implantation dysfunction is often overlooked as a significant reason for IVF failure. This is especially true when IVF failure is unexplained, or when there are…
Immunology & Implantation Mar 6, 2025

RIF

Dear dr Sher, I got my first child 2020 via embryodonation (34 yo) on the first attempt with HRT. I had low AMH and endo. Since 2024 we had 3 more embryotransfers (1 was PGT-a) tested with the same male… — Anna L.

Dr. Geoffrey Sher answered

We should really discuss this at length. It sounds to me as if you have an implantation dysfunction. Please read the article below and if interested in having an online consultation with me, contact my assistant, Patti Converse (concierge@sherivf.com) and set up an online consultation with me to…
Immunology & Implantation Feb 27, 2025

Miscarriages

Hello! I am writing to you about my current pregnancy… I have a chronic spontaneous allergy, and since several bumps appeared on my body, my hCG is no longer increasing as it should (21.02-5300/24.02-7800/26.02-8030)… I have two miscarriages, I know… — Patricia C.

Dr. Geoffrey Sher answered

Please read the article below. Thereupon, if you wish to have an online consultation with me to discuss you case in detail, please contact my assistant, Patti Converse (concierge@sherivf.com) and she will set this up. Geoffrey Sher MD UNDERSTANDING RECURRENT PREGNANCY LOSS ( RPL): CAUSES AND SOLUTIONS. When…
Immunology & Implantation Feb 21, 2025

IVF and high TPO antibodies

Hi Dr. Geoffrey Sher, I have a question regarding IVF. I have high TPO ( 4,843)but my TSH and t4,t3 are at normal level. Should I start IVF procedure ( my AMH is 0.053)and I am 39. Your advice will… — Olga M.

Dr. Geoffrey Sher answered

Between 2% and 5% of women of the childbearing age have reduced thyroid hormone activity (hypothyroidism). Women with hypothyroidism often manifest with reproductive failure i.e. infertility, unexplained (often repeated) IVF failure, or recurrent pregnancy loss. The condition is 5-10 times more common in women than in men. In…
Immunology & Implantation Jan 16, 2025

Repeated Implantation Failures and MC

Good morning Dr. Sher, My name is Xuandao ("Dao") Nguyen, I'm 42 yo and currently in round 4 of IVF at my local clinic here in Atlanta (ACRM). I want to give you a brief summary of my case and… — Xuandao N.

Dr. Geoffrey Sher answered

In my opinion, you have a likely implantation dysfunction . It could be anatomical or immunologic. I suggest you contact my assistant, Patti at concierge@sherIVF.com to set up an online consultation with me. Implantation dysfunction is often overlooked as a significant reason for IVF failure. This is especially…
Immunology & Implantation Jan 11, 2025

Probable cause of Infetility Immune Related

Good day Dr Sher I hope you are well. My name is Candice Castle, I am a functional health practitioner and you assisted me years ago with what medication to import into South africa so that I could have a… — Candice C.

Dr. Geoffrey Sher answered

Dear Candice, Thank you for your kind sentiments. It is a pleasure and privilege to be of service. It certainly sounds as if your patient likely has an implantation dysfunction. Please advise her to read the information below carefully and to access the e-book attachments below for more…

Ask Our Doctors

Supporting Your Journey

Our Medical Directors are outstanding physicians that you will find to be very personable and compassionate, who take care to ensure that you have the most cutting-edge fertility treatments at your disposal. This is your outlet to ask your questions to the doctors.

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