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Frozen Embryo Transfer (FET): A Rational Approach to Hormonal Preparation and How new Methodology is Impacting IVF

Until about 15 years ago, we believed that the best and safest way to
cryopreserve embryos was by using a slow freezing method. What we
subsequently learned was that the slow freezing process caused the
formation of intracellular ice and that this, by damaging embryos and
compromised their post-thaw survival as well as IVF outcome,
significantly. The introduction of ultra-rapid embryo freezing
(vitrification) has changed all that. With vitrification, embry…

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Anti Mullerian Hormone (AMH) Measurement to Assess Ovarian Reserve and Design the Optimal Protocol for Controlled Ovarian Stimulation (COS) in IVF

Anti-Müllerian hormone also known as AMH is a protein that, is
encoded by the AMH gene located on chromosome 19p13.3,. There is an
important interaction between AM and its receptor AMHR2 on chromosome
12. AMH is a glycoprotein hormone secreted by Granulosa cells in
developing follicles. AMH blood levels in a woman’s blood is an
indicator of the

Anti Mullerian Hormone (AMH) Measurement to Assess Ovarian Reserve and Design the Optimal Protocol for Controlled Ovarian Stimulation (COS) in IVF Read More »

Molar Pregnancy: What is it and How Should it be Treated?

Molar pregnancy or hydatidiform mole — is a benign tumor that occurs
in the uterus. It starts when an egg is fertilized, but instead
developing into a normal, conceptus + placental tissue, the placenta
tissue develops into a mass of small cysts. Here, the root system
(trophoblast) of the embryo which under normal conditions develops
into the placenta that connects the baby to the mother. With molar
pregnancy, the roots of the trophoblast (chorionic villi) un…

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IVF Outcome: How Age, Ovarian Reserve and the Protocol Used for Controlled Ovarian Stimulation (COS) Influences Success

It is the egg’s numerical chromosomal integrity (ploidy) that is the
most influential in influencing its subsequent ability
post-fertilization, to propagate a “competent” embryo (one that
has 46 chromosomes and is capable of developing into a healthy
pregnancy). And it is the ploidy of the embryo that determines
reproductive success. Thus, egg ploidy is the rate-limiting factor in
human reproduction.   Ovarian reserve refers to the number of eggs
remaining in the ovaries. An AMH o…

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Immunologic Implantation Dysfunction: Importance of Meticulous Evaluation and Strategic Management: (Case Report)

Greetings Dr. Sher! Just wanted to first thank you for all that you do
for women and infertility and I’m truly amazed and grateful at how
you are so willingly to share your knowledge and help women achieve
pregnancy. As for me, my background – Diagnosed with endometriosis
at age 19 when I lost one ovary/tube. Struggled with recurrent endo
and had multiple surgeries for endometriomas. Stayed on continuous BCP
for more than 15 years. At about 37 tried a few rounds of in vitro,
low slow…

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IVF: The Economic Realities

Patrick Steptoe and Robert Edwards were responsible for the birth of
the world’s 1st IVF baby, Louise Brown, in 1978. Since then about 4
million babies have been born worldwide, and the number is growing
fast. The introduction of this Assisted Reproductive technology (ART)
which comprises IVF and associated procedure has literally
revolutionized the treatment of infertility and Reproductive failure
b…

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