Understanding Recurrent Pregnancy Loss (RPL): Causes And Solutions

Understanding Recurrent Pregnancy Loss (RPL): Causes And Solutions

When it comes to reproduction, humans face challenges compared to other mammals. A significant number of fertilized eggs in humans do not result in live births, with up to 75% failing to develop, and around 30% of pregnancies ending within the first 10 weeks  (first...
IVF Failure With “Normal” Embryos:  Examining and Addressing  Anatomical and Immunologic Causes

IVF Failure With “Normal” Embryos: Examining and Addressing Anatomical and Immunologic Causes

Implantation dysfunction is often overlooked as a significant reason for IVF failure. This is especially true when IVF failure is unexplained, or when there are recurring pregnancy losses or underlying issues with the uterus, such as endo-uterine surface lesions, thin...
Embryo Implantation Dysfunction

Embryo Implantation Dysfunction

Implantation dysfunction is unfortunately often overlooked as an important cause of IVF failure. This is especially relevant in cases of unexplained IVF failure, recurrent pregnancy loss (RPL), and in women with underlying endo-uterine surface lesions, thickness of...
Disruption in the relationship between KIR, HLA, and NK cell activity and embryo implantation dysfunction: how to assess this

Disruption in the relationship between KIR, HLA, and NK cell activity and embryo implantation dysfunction: how to assess this

I constantly receive inquiries from “confused” patients with unexplained recurrent IVF failure, unexplained infertility, recurrent pregnancy loss etc. (where an immunologic implantation dysfunction (IID) is often underlying) as to the relevance of measuring Killer...
Immunologic Implantation Dysfunction: Importance of Meticulous Evaluation and Strategic Management: (Case Report)

Immunologic Implantation Dysfunction: Importance of Meticulous Evaluation and Strategic Management: (Case Report)

Greetings Dr. Sher! Just wanted to first thank you for all that you do for women and infertility and I’m truly amazed and grateful at how you are so willingly to share your knowledge and help women achieve pregnancy. As for me, my background – Diagnosed with...