by Dr. Geoffrey Sher | Jun 28, 2023 | Alloimmune, Alloimmune Implantation Dysfuction, Autoimmune, IID, Immunologic, Immunologic Implantation Dysfunction, Immunology, In Vitro Fertilization, IVF, IVF Failure, IVF for older women, IVF Genetic Screening, IVF Outcome
Implantation dysfunction is often overlooked as a significant reason for IVF failure. This is especially true when IVF failure is unexplained, or when there are recurring pregnancy losses or underlying issues with the uterus, such as endo-uterine surface lesions, thin...
by Dr. Geoffrey Sher | Apr 25, 2023 | Alloimmune, Alloimmune Implantation Dysfuction, Autoantibodies, Autoimmune, Embryo, Embryo Incompetency, Endometriosis, Endometrium, Failed IVF, IID, Immunologic, Immunologic Implantation Dysfunction, Immunology, Implantation, Intralipid, IVF, IVF Failure, NKA, Pregnancy Loss, Vaginal Viagra
Implantation dysfunction is unfortunately often overlooked as an important cause of IVF failure. This is especially relevant in cases of unexplained IVF failure, recurrent pregnancy loss (RPL), and in women with underlying endo-uterine surface lesions, thickness of...
by Dr. Geoffrey Sher | Apr 17, 2023 | Failed IVF, HLA, IID, Immunologic Implantation Dysfunction, Immunology, Implantation, Infertility, IVF Failure, KIR, MHC, NKA
I constantly receive inquiries from “confused” patients with unexplained recurrent IVF failure, unexplained infertility, recurrent pregnancy loss etc. (where an immunologic implantation dysfunction (IID) is often underlying) as to the relevance of measuring Killer...
by Dr. Geoffrey Sher | Feb 23, 2022 | Alloimmune, Autoimmune, IID
Currently there are fewer than a dozen immunology reference laboratories in the U.S that are capable of analyzing the required elements with a sufficient degree of sensitivity and specificity as to be reliable in my opinion. These elements include measuring blood...
by Dr. Geoffrey Sher | Feb 22, 2022 | IID, Immunology
In 15-20% of women who have infertility or RPL, the cause will be immunologic implantation dysfunction (IID). Accordingly, all women who have predisposing factors such as endometriosis, unexplained infertility/repeated failed IVF, RPL, or have a personal/family...
by Dr. Geoffrey Sher | Nov 1, 2021 | Autoimmune, Donor, Endometriosis, Genotype, IID, Immunologic, Miscarriage, Pregnancy Loss
Central to making a diagnosis of an immunologic implantation dysfunction (IID) is a need for the appropriate interpretation of Natural Killer Cell Activity (NKa). In this regard, one of the commonest and most serious errors, is interpret the blood concentration of...
