Understanding Recurrent Pregnancy Loss (RPL): Causes And Solutions

Understanding Recurrent Pregnancy Loss (RPL): Causes And Solutions

When it comes to reproduction, humans face challenges compared to other mammals. A significant number of fertilized eggs in humans do not result in live births, with up to 75% failing to develop, and around 30% of pregnancies ending within the first 10 weeks  (first...
IVF Failure With “Normal” Embryos:  Examining and Addressing  Anatomical and Immunologic Causes

IVF Failure With “Normal” Embryos: Examining and Addressing Anatomical and Immunologic Causes

Implantation dysfunction is often overlooked as a significant reason for IVF failure. This is especially true when IVF failure is unexplained, or when there are recurring pregnancy losses or underlying issues with the uterus, such as endo-uterine surface lesions, thin...
Embryo Implantation Dysfunction

Embryo Implantation Dysfunction

Implantation dysfunction is unfortunately often overlooked as an important cause of IVF failure. This is especially relevant in cases of unexplained IVF failure, recurrent pregnancy loss (RPL), and in women with underlying endo-uterine surface lesions, thickness of...
Treatment of Recurrent Pregnancy Loss (RPL) due to Alloimmune Implantation Dysfunction : Comparing cases with a  “Partial” versus a “Complete” Match (rare)

Treatment of Recurrent Pregnancy Loss (RPL) due to Alloimmune Implantation Dysfunction : Comparing cases with a “Partial” versus a “Complete” Match (rare)

 All humans have two DQ-alpha genes, one of which is contributed by the father and the other by the mother. In a small percentage of patients undergoing IVF, paternal-maternal DQ-alpha gene similarities occur. In such cases, following repeated exposures to such...