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Our Medical Directors are outstanding physicians that you will find to be very personable and compassionate, who take care to ensure that you have the most cutting-edge fertility treatments at your disposal. This is your outlet to ask your questions to the doctors.

Dear Patients,

I created this forum to welcome any questions you have on the topic of infertility, IVF, conception, testing, evaluation, or any related topics. I do my best to answer all questions in less than 24 hours. I know your question is important and, in many cases, I will answer within just a few hours. Thank you for taking the time to trust me with your concern.

– Geoffrey Sher, MD

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Immunology & Implantation Mar 6, 2025

RIF

Dear dr Sher, I got my first child 2020 via embryodonation (34 yo) on the first attempt with HRT. I had low AMH and endo. Since 2024 we had 3 more embryotransfers (1 was PGT-a) tested with the same male… — Anna L.

Dr. Geoffrey Sher answered

We should really discuss this at length. It sounds to me as if you have an implantation dysfunction. Please read the article below and if interested in having an online consultation with me, contact my assistant, Patti Converse (concierge@sherivf.com) and set up an online consultation with me to…
Embryos & Genetic Testing Mar 3, 2025

RIF

We have had 1 successful implantation which ended in a miscarriage at 8 weeks. 1 chemical pregnancy and 4 failed implantation - 3 of which were with euploid embryos. Husband has poor SA (varicocele) and I have been diagnosed with… — Z M.

Dr. Geoffrey Sher answered

Respectfully, Elevated DFI does not negatively affect implantation. What you are experiencing is likely an implantation dysfunction which could be "immunologic" in origin and linked to endometriosis....see below. I suggest you contact my assistant, Patti Converse (concierge@sherivf.com and ask her to set up with an online consultation with…
Immunology & Implantation Feb 27, 2025

Miscarriages

Hello! I am writing to you about my current pregnancy… I have a chronic spontaneous allergy, and since several bumps appeared on my body, my hCG is no longer increasing as it should (21.02-5300/24.02-7800/26.02-8030)… I have two miscarriages, I know… — Patricia C.

Dr. Geoffrey Sher answered

Please read the article below. Thereupon, if you wish to have an online consultation with me to discuss you case in detail, please contact my assistant, Patti Converse (concierge@sherivf.com) and she will set this up. Geoffrey Sher MD UNDERSTANDING RECURRENT PREGNANCY LOSS ( RPL): CAUSES AND SOLUTIONS. When…
Embryos & Genetic Testing Feb 23, 2025

RPL

I am a 42 year old women undergoing IVF treatment. I had a very successful egg retrieval (13 fertilized eggs, 9 blastocyst, after PGT-A testing: 3 euploid embryos and 1 low mosaic). We transfered our 3rd euploid embryo 2 weeks… — Lindsey M.

Dr. Geoffrey Sher answered

At 42y, IUI is definitely not the answer..please read below and thereupon (if so inclined) contact my assistant, Patti Converse (concierge@sherivf.com) and have her set up an online consultation with me. IMPLANTATION DYSFUNCTION Implantation dysfunction is often overlooked as a significant reason for IVF failure. This is especially…
Immunology & Implantation Jan 16, 2025

Repeated Implantation Failures and MC

Good morning Dr. Sher, My name is Xuandao ("Dao") Nguyen, I'm 42 yo and currently in round 4 of IVF at my local clinic here in Atlanta (ACRM). I want to give you a brief summary of my case and… — Xuandao N.

Dr. Geoffrey Sher answered

In my opinion, you have a likely implantation dysfunction . It could be anatomical or immunologic. I suggest you contact my assistant, Patti at concierge@sherIVF.com to set up an online consultation with me. Implantation dysfunction is often overlooked as a significant reason for IVF failure. This is especially…
Embryos & Genetic Testing Jan 11, 2025

Eight losses

Hello, my name is Vikki Carpenter. I am 40 years old and started IVF last year. I have one IVF failure (chemical), and 7 other chemical pregnancies before IVF. The pattern is virtually the same: I get pregnant and within… — Vikki C.

Dr. Geoffrey Sher answered

UNDERSTANDING RECURRENT PREGNANCY LOSS ( RPL): CAUSES AND SOLUTIONS. When it comes to reproduction, humans face challenges compared to other mammals. A significant number of fertilized eggs in humans do not result in live births, with up to 75% failing to develop, and around 30% of pregnancies ending…
IVF Failure & Pregnancy Loss Jan 11, 2025

Reoccurring-Implantation Failure

Dear Dr. Sher, My husband and I are trying to get pregnant for a while. The last test that they performed was taking a tissue sample from my uterus, and the results showed periglandular clusters in NK cells (CD138). My… — Silvia H.

Dr. Geoffrey Sher answered

IMPLANTATION DYSFUNCTION Implantation dysfunction is often overlooked as a significant reason for IVF failure. This is especially true when IVF failure is unexplained, or when there are recurring pregnancy losses or underlying issues with the uterus, such as endo-uterine surface lesions, thin uterine lining (endometrium), or immunological factors.…
Embryos & Genetic Testing Jan 11, 2025

Recurrent pregancy loss and ivf failures cause

I had 3 natural pregnancies that ended up in miscarriages and 3 embryos pgt tested implanted that failed. I want to know the cause — Joyce M.

Dr. Geoffrey Sher answered

UNDERSTANDING RECURRENT PREGNANCY LOSS ( RPL): CAUSES AND SOLUTIONS. When it comes to reproduction, humans face challenges compared to other mammals. A significant number of fertilized eggs in humans do not result in live births, with up to 75% failing to develop, and around 30% of pregnancies ending…
Embryos & Genetic Testing Nov 22, 2024

Opinion on french MatriceLab test

Dear Dr. Sher, Thank you for the detailed article on immunological issues of embryo implantation failures. I'm writing to you as a fertility patient in France. After a certain number of blastocysts transfered with a single implantation and early miscarriage,… — Manon G.

Dr. Geoffrey Sher answered

I aplaud any research that serves to uncover the immunologic basis for implantation dysfunction. Endometrial local immunity is likely an important parameter that influences implantation and the the prognosis of pregnancy.. Diagnosis of an endometrial immune dysregulation . It seeks to assess embryo-endometrial interaction and focuses on several…
Embryos & Genetic Testing Nov 14, 2024

Recurrent implantation failures

Dear Dr. Sher, Myself and husband are both 38 yrs old started our fertility journey at the age of 32 yrs so trying to conceive for 6 yrs now. We started with ovulation induction, had an ectopic treated with methotrexate.… — Remy A.

Dr. Geoffrey Sher answered

Implantation dysfunction is often overlooked as a significant reason for IVF failure. This is especially true when IVF failure is unexplained, or when there are recurring pregnancy losses or underlying issues with the uterus, such as endo-uterine surface lesions, thin uterine lining (endometrium), or immunological factors. IVF success…
Immunology & Implantation Nov 11, 2024

RIF

Hi there, We had a son nearly 5 years ago within a few months of trying (cesarian), since then we have had a blighted ovum, 1 chemical pregnancy, 1 6 week miscarriage trisomy 8, and 10 failed implantations (of high… — Sean T.

Dr. Geoffrey Sher answered

This sounds very much like an anatomical implantation dysfunction (see below). I suggest we talk. Please contact my assistant, Patti Converse at 702-533-2691 to set this up. Geoff Sher IVF FAILURE WITH “NORMAL” EMBRYOS: EXAMINING AND ADDRESSING ANATOMICAL AND IMMUNOLOGIC CAUSES. Implantation dysfunction is often overlooked as a…
IVF Failure & Pregnancy Loss Nov 8, 2024

Recurrent pregnancy loss

Hi, I have RPL, and have 4 miscarriages this last year. Now done IVF with 13 eggs, 11 fertilized and only 2 made blasto at day 6. I have RA, mild endo. I take enbrel 50 mg 1xw and my… — Helene N.

Dr. Geoffrey Sher answered

When it comes to reproduction, humans face challenges compared to other mammals. A significant number of fertilized eggs in humans do not result in live births, with up to 75% failing to develop, and around 30% of pregnancies ending within the first 10 weeks (first trimester). Recurrent pregnancy…
Egg Health & Ovarian Reserve Sep 30, 2024

It’s over

Dear Dr. Sher, I am 43 years old, and in the last 2 years: 6 cycles, 100 follicles, 90 oocytes collected, 60 oocytes matured, 50 embryos, 10 blastocytes, 1 euploid. One abortion (prior to ivf), two failed transfers (the euploid… — Anne C.

Dr. Geoffrey Sher answered

I think we should talk first before you make that determination definitively. If you are interested in having an online consultation with me, please contact my assistant, Patti Converse at 702-533-2691 or email her at concierge@sherivf.com\ Geoff Sher ADDRESSING ADVANCING AGE AND DIMINISHING OVARIAN RESERVE (DOR) IN IVF…
IVF Failure & Pregnancy Loss Sep 17, 2024

Hysteroscopy result

Hi, I have had 3 natural miscarriages, but 3 failed implantations with PGT embryos. I got a hysteroscopy, and they found dyssynchronous proliferative endometrium and polypoid dyssynchronous proliferative endometrium consistent with endometrial polyp. Can this have any impact in my… — Laura C.

Dr. Geoffrey Sher answered

UNDERSTANDING RECURRENT PREGNANCY LOSS ( RPL): CAUSES AND SOLUTIONS. When it comes to reproduction, humans face challenges compared to other mammals. A significant number of fertilized eggs in humans do not result in live births, with up to 75% failing to develop, and around 30% of pregnancies ending…
IVF Failure & Pregnancy Loss Sep 10, 2024

IVF

For egg retrival they got 7 eggs 4 eggs died why is this — Tammy S.

Dr. Geoffrey Sher answered

I would neede to know much morev to comment authoritatively! Geoff Sher PLEASE SHARE THIS WITH OTHERS AND HELP SPREAD THE WORD!! Herewith are online links to 2 E-books recently co-authored with my partner at SFS-NY (Drew Tortoriello MD)....... for your reading pleasure: From In Vitro Fertilization to…

Ask Our Doctors

Supporting Your Journey

Our Medical Directors are outstanding physicians that you will find to be very personable and compassionate, who take care to ensure that you have the most cutting-edge fertility treatments at your disposal. This is your outlet to ask your questions to the doctors.

177 answers

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