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Our Medical Directors are outstanding physicians that you will find to be very personable and compassionate, who take care to ensure that you have the most cutting-edge fertility treatments at your disposal. This is your outlet to ask your questions to the doctors.

Dear Patients,

I created this forum to welcome any questions you have on the topic of infertility, IVF, conception, testing, evaluation, or any related topics. I do my best to answer all questions in less than 24 hours. I know your question is important and, in many cases, I will answer within just a few hours. Thank you for taking the time to trust me with your concern.

– Geoffrey Sher, MD

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Age & Fertility Mar 24, 2023

Adenomyosis, AMH and advanced maternal age

Hello Dr, Sher, from one South African to another :) I am living in Portugal now, and am trying to fall pregnant. I have been diagnosed with diffuse adenomyosis (mild) which is at the top of my uterus. Mainly on… — Lisa-Marie E.

Dr. Geoffrey Sher answered

Respectfully, I do not agree. Both age and diminishing ovarian reserve, make this a poor choice. I would move to IVF ASAP . Frankly , unless your adenomyosis is associated with a "thin uterine lining at mid-cycle, I would not be over concerned about this aspect.I am including…
Uterine & Endometrial Health Mar 23, 2023

Trilaminar Endometrium

Dear Dr. Sher, Thank you so much for your dedication to answering all our questions. I have a problem concerning the endometrium. Mine gets thick enough but never trilaminar anymore (it was like that for the last three attempts). I… — Shira M.

Dr. Geoffrey Sher answered

In my opinion, the trilaminar configuration is NOT important. It is endometrial thickness that matters. This needs to be >8mm on the day of "the trigge3r" or the start of progesterone. Geoffrey Sher It was as far back as 1989, when I first published a study that examined…
Uterine & Endometrial Health Mar 23, 2023

Anatomy

What is Inflammation of uterus — Ali-abbas M.

Dr. Geoffrey Sher answered

Endometritis where the endometrial lining becomes infected and inflamed, raising the possibility of an implantation dysfunction. Geoff Sher ADDITIONAL INFORMATION: I am attaching online links to two E-books which I recently co-authored with my partner at SFS-NY (Drew Tortoriello MD)....... for your reading pleasure: 1.From In Vitro Fertilization…
Uterine & Endometrial Health Mar 21, 2023

Thick uterine lining

I usually have a thick lining and went in for US and it's already at 11 after 6 days of estrogen (one 0.10mg patch March 15 and changed the patch on Saturday to a new 0.10mg patch).. When I went… — Rennae F.

Dr. Geoffrey Sher answered

As long as there is no endometrial pathology there is no such thing as a "too thick" endometrium. Geoff Sher ADDITIONAL INFORMATION: I am attaching online links to two E-books which I recently co-authored with my partner at SFS-NY (Drew Tortoriello MD)....... for your reading pleasure: 1.From In…
Egg Health & Ovarian Reserve Mar 9, 2023

IVF & Endometriosis

37 yrs old, 1.6 amh. 7 years of infertility, 4 failed IUI's before surgery, 2 surgeries to remove endometriosis and endometriomas on both ovaries, 1 IVF completed and obtained one normal 5BB embreyo. What protocol is best for 2nd IVF… — Jule A.

Dr. Geoffrey Sher answered

ENDOMETRIOSIS AND IVF When women with infertility due to endometriosis seek treatment, they are all too often advised to first try ovarian stimulation (ovulation Induction) with intrauterine insemination (IUI) ………as if to say that this would be just as likely to result in a baby as would in…
Uterine & Endometrial Health Mar 7, 2023

Progesterone dose and levels concern

My doctor tested my progesterone (P) levels 1 day after 5 day transfer and said it was 103 (Canadian units) but that it should be 50-100. He dropped my dose from 50 mg PIO to 12.5 mg without rechecking it… — Lauren C.

Dr. Geoffrey Sher answered

The decision is between you and your treating RE. I might have done differently, but I doubt it will make a difference. Good luck! Geoff Sher ADDITIONAL INFORMATION: I am attaching online links to two E-books which I recently co-authored with my partner at SFS-NY (Drew Tortoriello MD).......…
Immunology & Implantation Mar 6, 2023

High Foxp3 T-Cells

Hi Dr Sher, My Proliferative Phase Endometrium Immune Cell Studies on CD9 came back with Natural Killer Cells present at 5.1% and Foxp3 cells at 26/mm2. My fertility specialist has included in my next treatment plan for a FET for… — Katrina P.

Dr. Geoffrey Sher answered

I am sending you a copy of my book on immunology. You will see that I use a different approach for fixing on treatment. Geoff Sher Currently, with few exceptions, practitioners of assisted reproduction tend to attribute “unexplained and/or repeated” IVF failure(s), almost exclusively to poor embryo quality,…
IVF Failure & Pregnancy Loss Mar 4, 2023

Multiple IVF fails

Hi Dr. Sher thank you for your time. I’m 45 mother of 2 -18 &17 yr olds(normal pregnancies) I been doing IVF for the past 3 years. I’m currently on my 8th treatment with sperm & egg donor. I’ve had… — Ashley T.

Dr. Geoffrey Sher answered

Whenever a patient fails to achieve a viable pregnancy following embryo transfer (ET), the first question asked is why! Was it simply due to, bad luck?, How likely is the failure to recur in future attempts and what can be done differently, to avoid it happening next time?.…
Hormones & Ovulation Feb 26, 2023

IVF failure 1x

I just went through my 1st IVF transfer on 2/15/23, I have found out I failed. My uterus lining was 9+ , Embryo was 4AA. I am wondering if it’s my natural killer cells. I had Endometriosis and a Septate… — Marisa T.

Dr. Geoffrey Sher answered

Whenever a patient fails to achieve a viable pregnancy following embryo transfer (ET), the first question asked is why! Was it simply due to, bad luck?, How likely is the failure to recur in future attempts and what can be done differently, to avoid it happening next time?.…
Uterine & Endometrial Health Feb 24, 2023

**correction ** progesterone levels after FET

I need to edit my previous post that my PIO dose was 50 mg once daily prior to FET then dropped to 12.5mg after P levels were checked day after FET — Lauren C.

Dr. Geoffrey Sher answered

Same answer! Geoff Sher
Uterine & Endometrial Health Feb 24, 2023

Progesterone levels after FET

Hi Dr SHER, my clinic’s FET protocol has me on both progesterone vaginal capsules 200mg 3x/day plus 100mg PIO once daily in preparation for FET. They tested my levels day before transfer and was good; they tested day after and… — Lauren C.

Dr. Geoffrey Sher answered

I strongly doubt any adverse effect! Good luck! Geoff Sher ADDITIONAL INFORMATION: I am attaching online links to two E-books which I recently co-authored with my partner at SFS-NY (Drew Tortoriello MD)....... for your reading pleasure: 1.From In Vitro Fertilization to Family: A Journey with Sher Fertility Solutions…
Clinic & Practice Feb 14, 2023

New Pathway without a referral

Hello, I was referred to you from great friends of mine and I’m already impressed that there is a question portal! My husband and I would like to change doctors and don’t have a referral. Would we need one to… — Deanna F.

Dr. Geoffrey Sher answered

I would be delighted to consult with you. Please contact my assistant, Patti Converse at 702-533-2691 and set up an online consultation with me. I look forward to meeting both you and your husband. Geoff Sher ADDITIONAL INFORMATION: I am attaching online links to two E-books which I…
Ovarian Stimulation & OHSS Feb 13, 2023

Clomiphene

Hi Dr. Sher, I am 42, trying for our 2nd baby. I had regular periods and ovulated well till October 2022 when My OB doctor prescribed Clomiphene x5 days. My cycles became mess after that. Periods last for 16-17 days,… — Iryna S.

Dr. Geoffrey Sher answered

Clomiphene (syn; Clomid , Serophene) is by far the most widely prescribed agent for the induction of human ovulation for women who do not ovulate, those with dysfunctional ovulation and women with ”unexplained” infertility. When used in young women (who have adequate ovarian reserve) with these problems the…
Embryos & Genetic Testing Feb 9, 2023

Sonohysterogram during a FET

Hi Dr Sher, do you believe its okay to get a Sonohysterogram done during cycle day 6 - 11 of a medicated Frozen Embryo Transfer cycle? Can the medication (Estrogen and Progesterone) interfere with the SHG results or vice-versa? — Jennifer L.

Dr. Geoffrey Sher answered

Respectfully! I personally would not perform a SNH during a cycle of FET! Geoff Sher ADDITIONAL INFORMATION: I am attaching online links to two E-books which I recently co-authored with my partner at SFS-NY (Drew Tortoriello MD)....... for your reading pleasure: 1.From In Vitro Fertilization to Family: A…
Ovarian Stimulation & OHSS Jan 28, 2023

Thin uterine lining after egg retrieval

Is it possible to have damaged the lining of my uterus during egg retrieval? My uterine lining went from 9.9mm 2 days before egg retrieval to 5mm after. Please advise. — Shernelle T.

Dr. Geoffrey Sher answered

That is highly unusual. The ER would not have caused this. Perhaps one of these measurements was not accurate. It was as far back as 1989, when I first published a study that examined the correlation between the thickness of a woman’s uterine lining (the endometrium), and the…

Ask Our Doctors

Supporting Your Journey

Our Medical Directors are outstanding physicians that you will find to be very personable and compassionate, who take care to ensure that you have the most cutting-edge fertility treatments at your disposal. This is your outlet to ask your questions to the doctors.

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