Causes of Infertility

Infertility is defined as inability to conceive in spite of engaging in well-timed unprotected sex for more than one year. The causes of infertility are multiple and are often difficult to define but may include anatomical conditions involving tubal patency and/or function as well as diseases of the testicles and/or or sperm ducts, dysfunctional levels […]

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Sher Fertility Solutions

Staggered-In Vitro Fertilization (ST- IVF) : A Paradigm Shift: Heralded by the Introduction of Ultrarapid Embryo/Egg Freezing (Vitrification)

Cryopreservation of human embryos has been a routine procedure since the early 1980s. Until quite recently, it involved a โ€œconventionalโ€ slow freezing process which unfortunately resulted in intracellular ice crystal formation which damaged embryos, destroying some and reducing the ability of most to propagate viable pregnancies. pregnancy. The introduction over the last 10-15 years of

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Adenomyosis

Adenomyosis is a prevalent gynecological disease in which endometrial (uterine lining) cells invade into the uterine muscle layer (myometrium). This ectopically located endometrial tissue is functional, proliferating and โ€œmenstruatingโ€ during every menstrual cycle. The ensuing inflammation will permeate into the uterine muscle, causing it to undergo hyperplastic changes leading to a bulkier, heavier, and occasionally tender uterus. The prevalence of adenomyosis may be as high as 35% of reproductive-age women and typically presents with painful and heavy menses.

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IVF Using Own Eggs : When is it Time to Move on?

Because of the emotional, physical, and financial toll exacted by IVF, it is preferable that no one undertake a oneโ€‘shot attempt. If a couple can only afford one treatment cycle, IVF is probably not the right course of action.ย  After all, with conventional IVF there is only about one chance in three that it will result in a live birth โ€‘and a tremendous letdown if it fails. It is thus unreasonable to undergo IVF with the attitude that “if it doesn’t work the first time, we’re giving up.” In vitro fertilization is a gamble even in the best of circumstances.

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Intraovarian PRP โ€“ a promising technique that requires more investigation

ย 
Platelet-rich-plasma, or PRP, is a fraction of blood obtained upon
centrifugation that is enriched for cells called platelets. Other
cells, including white blood cells and red blood cells are ideally
excluded.ย  Platelets have been shown to secrete chemicals that
facilitate clot formation and are vital in preventing excessive
bleeding in humans, but they are also capable of secreting other
factors that facilitate cell growth and tissue repair. It is for this
restorative capacity…

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Sher Fertility Solutions

A RATIONAL BASIS FOR SELECTIVE OVARIAN STIMULATION IN OLDER WOMEN AND THOSE WITH DIMINISHED OVARIAN RESERVE (DOR)

ย 

_WHEN IT COMES TO THE SELECTION OF OVARIAN STIMULATION PROTOCOLS FOR
OLDER WOMEN AND THOSE WHO HAVE DOR THERE IS IN MY OPINION, NO
JUSTIFICATION FOR THE USE OF A โ€œONE SIZE FITS ALLโ€ OR โ€œRECIPE
APPROACHโ€. I FIRMLY BELIEVE THAT THE TIME HAS ARRIVED TO REFLECT
SERIOUSLY ON AN INDIVIDUALIZED SELECTION OF OVARIAN STIMULATION
PROTOCOLS THAT WOULD OPTIMIZE EGG/EMBRYO QUALITY, RATHER THAN SIMPLY
TRYING TO MAXIMIZE THE TOTAL EGG YIELD._
A woman is bo…

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Starting Your Journey With SFS

Starting Your Journey With SFS

ย 
Infertility treatment encompasses a wide range of possibilities, of
which IVF is only one option.ย  It is not the treatment of choice for
everyone.ย  However, while in the past, IVF was often considered the
last common pathway, today, due to a myriad of factors, IVF is
regarded as one of the mainstays for helping couples achieve the goal
of a healthy family.ย ย  In the final analysis, it is our
individualized approach to treatment and our emphasis on putting
patients at the fore…

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Sher Fertility Solutions

Treatment of Recurrent Pregnancy Loss (RPL) due to Alloimmune Implantation Dysfunction : Comparing cases with a โ€œPartialโ€ versus a โ€œCompleteโ€ Match (rare)

ย 
All humans have two DQ-alpha genes, one of which is contributed by the
father and the other by the mother. In a small percentage of patients
undergoing IVF, paternal-maternal DQ-alpha gene similarities occur. In
such cases, following repeated exposures to such genetically matching
embryos, this will provoke activation of the decidual immune system.
In most cases, repeated exposure to DQ alpha matching embryos will
over time activate uterine NK cells, resulting in reproductive dy…

Treatment of Recurrent Pregnancy Loss (RPL) due to Alloimmune Implantation Dysfunction : Comparing cases with a โ€œPartialโ€ versus a โ€œCompleteโ€ Match (rare) Read More ยป

Egg Freezing for Future Fertility

ย 

Many patients come to me in their late 30s and 40s to either assess
their relative fertility or to start fertility treatments, and they
are often unpleasantly surprised to find out that their ovarian
reserve is low. It might be age-appropriate or even lower than age
might predicate, but both scenarios are frequently met with
consternation.
We know that there are several things that can hasten ovarian
follicular demise and lower the egg count prematurely.ย  Among these
fact…

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