I was taking Buserilin daily for two weeks as a down regulation, prior to beginning stimulation for a frozen embryo transfer. One evening, I took my injection 2.5/3 hours late and the next day my cycle had to be cancelled because my estrogen was too high. My question is, did my estrogen rise that much within 24 hours?! (It was over 2000) And was it because of my late dose or was it because I simply did not respond to the medication at all basically. Help, I’m driving myself crazy.