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Our Medical Directors are outstanding physicians that you will find to be very personable and compassionate, who take care to ensure that you have the most cutting-edge fertility treatments at your disposal. This is your outlet to ask your questions to the doctors.

Dear Patients,

I created this forum to welcome any questions you have on the topic of infertility, IVF, conception, testing, evaluation, or any related topics. I do my best to answer all questions in less than 24 hours. I know your question is important and, in many cases, I will answer within just a few hours. Thank you for taking the time to trust me with your concern.

– Geoffrey Sher, MD

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Embryos & Genetic Testing May 29, 2025

Slow frozen

Dear Dr Sher! We have a patient who has 6 slow-frozen embryos. She wants to donated them to another family. WE attempted to find a recipient family for her; however, most fertility clinics do not want to accept slow frozen… — Alena W.

Dr. Geoffrey Sher answered

If they were frozen on day-3...indeed you could do that. But if they were frozen as blastocysts, the thaw-biopsy-refreeze can damage the embryos. Good luck Geoff Sher ADDITIONAL INFORMATION: Herewith are online links to 2 E-books recently co-authored with my partner at SFS-NY (Drew Tortoriello MD)....... for your…
Early Pregnancy & hCG Apr 27, 2025

To know much about my IVF journey

Thank you for receive me, what if my LH level is higher (15,45 mIU/ml on Day 3 of menstrual cycle — Paola U.

Dr. Geoffrey Sher answered

I would need much more information. If you would like to discuss your case with me , email my assistant (702-533-2691 and set up an online consultation with me,
Early Pregnancy & hCG Apr 1, 2025

FET

Hi Dr Sher I’m 38 y/o and and going through fertility treatment using donor sperm. I have just had an unsuccessful fresh ICSI embryo transfer (6 eggs retrieved, 6 fertilised, grade A embryo transferred, 3 embryos frozen grades B B… — Liz D.

Dr. Geoffrey Sher answered

I Thank you for sharing your IVF treatment details. From what you’ve described, you are 38 years old and have recently undergone your second IVF cycle, during which three cleaved embryos of reasonable quality were transferred, but unfortunately, conception did not occur. In your first cycle, a single…
Embryos & Genetic Testing Mar 3, 2025

RIF

We have had 1 successful implantation which ended in a miscarriage at 8 weeks. 1 chemical pregnancy and 4 failed implantation - 3 of which were with euploid embryos. Husband has poor SA (varicocele) and I have been diagnosed with… — Z M.

Dr. Geoffrey Sher answered

Respectfully, Elevated DFI does not negatively affect implantation. What you are experiencing is likely an implantation dysfunction which could be "immunologic" in origin and linked to endometriosis....see below. I suggest you contact my assistant, Patti Converse (concierge@sherivf.com and ask her to set up with an online consultation with…
Embryos & Genetic Testing Feb 23, 2025

RPL

I am a 42 year old women undergoing IVF treatment. I had a very successful egg retrieval (13 fertilized eggs, 9 blastocyst, after PGT-A testing: 3 euploid embryos and 1 low mosaic). We transfered our 3rd euploid embryo 2 weeks… — Lindsey M.

Dr. Geoffrey Sher answered

At 42y, IUI is definitely not the answer..please read below and thereupon (if so inclined) contact my assistant, Patti Converse (concierge@sherivf.com) and have her set up an online consultation with me. IMPLANTATION DYSFUNCTION Implantation dysfunction is often overlooked as a significant reason for IVF failure. This is especially…
Embryos & Genetic Testing Feb 11, 2025

Article; IVF: FACTORS AFFECTING EGG/EMBRYO “COMPETENCY” DURING CONTROLLED OVARIAN STIMULATION (COS)

Quick question- sperm and egg cells, don' t they contain 23 chromosomes only as they are germ cells (Haploid cells) , and not 2x 23 as mentioned in this article? — Theivanya U.

Dr. Geoffrey Sher answered

Both sperm and eggs start off with 46 chromosomes. Then during meiosis (reproductive maturational division, the divide their chromosomes in half to 23 (the haploid number). The fusion of the sperm and the egg thereupon reconstitutes the chromosomes in the embryo to 46(the diploid number). Geoff Sher Herewith…
Egg Health & Ovarian Reserve Jan 23, 2025

Fertility at 41

Hello Dr Sher, I am a physician G3P2 who has gone through 6 cycles of IVF for my 3rd child. (My elder two are 11 and 9 who were naturally conceived and delivered NSVD). I have done luteal phase stimulation… — Heena P.

Dr. Geoffrey Sher answered

Thank you for reaching out to me. We should talk. I recommend that you contact my assistant, Patti Converse at concierge@sherivf.com and set up an online consultation with me to discuss. In the meanwhile, please see below. Geoff Sher ADDRESSING ADVANCING AGE AND DIMINISHING OVARIAN RESERVE (DOR) IN…
Clinic & Practice Jan 22, 2025

Consult with Dr. Sher

Recommendation regarding future IVF treatment- 41 y.o Female with DOR; multiple IVF cycles; embryos don't make it to blastocyst (only had 2 blastocysts) so far. — Neha K.

Dr. Geoffrey Sher answered

I agree! This requires an online consultation; I suggest you contact my assistant (Patti) and set this up with me. In the meanwhile, see below. Embarking on the journey of IVF often raises questions about the likelihood of success and the quality of embryos. While it’s challenging to…
Embryos & Genetic Testing Jan 11, 2025

Eight losses

Hello, my name is Vikki Carpenter. I am 40 years old and started IVF last year. I have one IVF failure (chemical), and 7 other chemical pregnancies before IVF. The pattern is virtually the same: I get pregnant and within… — Vikki C.

Dr. Geoffrey Sher answered

UNDERSTANDING RECURRENT PREGNANCY LOSS ( RPL): CAUSES AND SOLUTIONS. When it comes to reproduction, humans face challenges compared to other mammals. A significant number of fertilized eggs in humans do not result in live births, with up to 75% failing to develop, and around 30% of pregnancies ending…
Embryos & Genetic Testing Jan 11, 2025

News Reporter

hi, would love to talk to you about PGT testing for a story. — Amy K.

Dr. Geoffrey Sher answered

Please contact my assistant Patti (concierge@sherIVF.com. Geoff Sher Herewith are online links to 2 E-books recently co-authored with my partner at SFS-NY (Drew Tortoriello MD)....... for your reading pleasure: From In Vitro Fertilization to Family: A Journey with Sher Fertility Solutions (SFS) ; https://sherfertilitysolutions.com/sher-fertility-solutions-ebook.pdf Recurrent Pregnancy Loss and…
Embryos & Genetic Testing Jan 11, 2025

Recurrent pregancy loss and ivf failures cause

I had 3 natural pregnancies that ended up in miscarriages and 3 embryos pgt tested implanted that failed. I want to know the cause — Joyce M.

Dr. Geoffrey Sher answered

UNDERSTANDING RECURRENT PREGNANCY LOSS ( RPL): CAUSES AND SOLUTIONS. When it comes to reproduction, humans face challenges compared to other mammals. A significant number of fertilized eggs in humans do not result in live births, with up to 75% failing to develop, and around 30% of pregnancies ending…
Embryos & Genetic Testing Nov 27, 2024

Embryo Transfer

Is it normal take 10mg Prednisolone 5 days before transfer and 5 Progynova a day? If so, do you have any suggested reasons why this might be the case ? Also how do you improve blood circulation prior to transfer?… — Meshelley S.

Dr. Geoffrey Sher answered

Respectfully, I do not uses such an approach! Geoff Sher
Egg Health & Ovarian Reserve Nov 24, 2024

IVF

I am 28 and my husband is 27. My husband was diagnosed with male factor infertility 1 year ago (low count, low motility). Our first IVF round produced 17 eggs, 14 mature, 14 fertilized and 6 untested fair quality blasts.… — Payton D.

Dr. Geoffrey Sher answered

I do not think the reason for your failed cycles was due to the male factor. It sounds more like an implantation dysfunction. We should connect online and discuss this in depth. I think I can help. Please call my assistant, Patti Converse at 702-533-2691 and set up…
Embryos & Genetic Testing Nov 22, 2024

Opinion on french MatriceLab test

Dear Dr. Sher, Thank you for the detailed article on immunological issues of embryo implantation failures. I'm writing to you as a fertility patient in France. After a certain number of blastocysts transfered with a single implantation and early miscarriage,… — Manon G.

Dr. Geoffrey Sher answered

I aplaud any research that serves to uncover the immunologic basis for implantation dysfunction. Endometrial local immunity is likely an important parameter that influences implantation and the the prognosis of pregnancy.. Diagnosis of an endometrial immune dysregulation . It seeks to assess embryo-endometrial interaction and focuses on several…
Embryos & Genetic Testing Nov 14, 2024

Recurrent implantation failures

Dear Dr. Sher, Myself and husband are both 38 yrs old started our fertility journey at the age of 32 yrs so trying to conceive for 6 yrs now. We started with ovulation induction, had an ectopic treated with methotrexate.… — Remy A.

Dr. Geoffrey Sher answered

Implantation dysfunction is often overlooked as a significant reason for IVF failure. This is especially true when IVF failure is unexplained, or when there are recurring pregnancy losses or underlying issues with the uterus, such as endo-uterine surface lesions, thin uterine lining (endometrium), or immunological factors. IVF success…

Ask Our Doctors

Supporting Your Journey

Our Medical Directors are outstanding physicians that you will find to be very personable and compassionate, who take care to ensure that you have the most cutting-edge fertility treatments at your disposal. This is your outlet to ask your questions to the doctors.

223 answers

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